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Discovery of 4′-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
- Source :
-
Bioorganic & Medicinal Chemistry . Mar2019, Vol. 27 Issue 6, p991-1001. 11p. - Publication Year :
- 2019
-
Abstract
- Graphical abstract Abstract A series of 4′-OH flurbiprofen Mannich base derivatives were designed, synthesized and evaluated as potential multifunctional agents for the treatment of Alzheimer's disease. The biological screening results indicated that most of these derivatives exhibited good multifunctional activities. Among them, compound 8n demonstrated the best inhibitory effects on self-induced A β 1-42 aggregation (65.03% at 25.0 μM). Moreover, this representative compound also exhibited good antioxidant activity, biometal chelating ability and anti-neuroinflammatory activity in vitro. Furthermore, compound 8n displayed appropriate blood-brain barrier permeability. These multifunctional properties highlight compound 8n as promising candidate for further development of multi-functional drugs against AD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALZHEIMER'S disease treatment
*MANNICH bases
*BLOOD-brain barrier
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 27
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 135744527
- Full Text :
- https://doi.org/10.1016/j.bmc.2019.01.040