The prognostic value of nitrotyrosine levels in coronary heart disease: long-term evaluation in the Acute Coronary Syndrome Registry Strategy (ERICO study).

Abstract Introduction We aimed to analyze the association of nitrotyrosine (N-TYR) levels and long-term survival in an ongoing coronary heart disease (CHD) prospective cohort, the Acute Coronary Syndrome Registry Strategy (ERICO study). Methods N-TYR levels collected during acute and subacute phase from onset of acute coronary syndrome (ACS) symptoms (myocardial infarction and unstable angina) were evaluated in 342 patients. We calculated case-fatality rates (180-days, 1 year, 2 years and 4 years) and survival analyses up to 4 years using Kaplan-Meier curves and Cox regression with respective cumulative hazard ratios (95% confidence interval; 95%CI), according to N-TYR tertiles up to 4 years of follow-up. Models are presented as crude, age and sex-adjusted and further adjusted for lipids and other confounders. Results Overall, median level of N-TYR was 208.33 nmol/l (range: 3.09 to 1500 nmol/l), regardless ACS subtype. During follow-up of 4 years, we observed 44 (12.9%) deaths. Overall survival rate was 298 (87.1%) (Survival days: 1353, 95%CI: 1320–1387 days). N-TYR levels did not associate with mortality / survival rates up to 4 years. Conclusions No relationship was found between N-TYR levels and mortality rates after ACS during 4-year follow-up in the ERICO study. Highlights • Previous research suggested nitrotyrosine plays a role in CHD by oxidative stress. • However, there is a lack of evidence of nitrotyrosine influencing on CHD mortality. • Here, nitrotyrosine had no influence on acute coronary syndrome long-term survival. [ABSTRACT FROM AUTHOR]