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Enantioseparation of amino acid derivatives on an immobilized network polymer derived from l-tartaric acid
- Source :
-
Journal of Chromatography A . Jul2004, Vol. 1042 Issue 1/2, p81-87. 7p. - Publication Year :
- 2004
-
Abstract
- Seven structurally related amino acid derivatives were successfully enantioseparated by HPLC with a commercially available column containing a chiral immobilized network polymer derived from l-tartaric acid. The experiments were carried out under normal-phase conditions. All the solutes could be baseline separated using n-hexane/2-propanol (95/5) as eluent at a flow rate of 1 ml/min at 25 °C, with reasonable retention time (<12 min). The effects of the polar alcohol modifier (type and content) in the mobile phase and the column temperature on the enantioseparation were studied. Apparent thermodynamic parameters were also calculated from the plots of ln α or ln k′ versus 1/T. Some mechanistic aspects of chiral recognition were discussed with respect to the structures of the solutes. It was found that the enantioseparations are all enthalpy driven, and the N-acyl groups of the solutes have significant influence on the chiral recognition. [Copyright &y& Elsevier]
- Subjects :
- *AMINO acids
*POLYMERS
*TARTARIC acid
*HIGH performance liquid chromatography
Subjects
Details
- Language :
- English
- ISSN :
- 00219673
- Volume :
- 1042
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography A
- Publication Type :
- Academic Journal
- Accession number :
- 13562854
- Full Text :
- https://doi.org/10.1016/j.chroma.2004.05.058