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Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.
- Source :
-
Acta Neurochirurgica . Apr2019, Vol. 161 Issue 4, p761-765. 5p. 1 Color Photograph, 1 Chart. - Publication Year :
- 2019
-
Abstract
- Background: The relationship between increased meningioma incidence and growth and long-term hormonal therapy with cyproterone acetate (CPA) in women has been recently established in literature. Following the raise in awareness from hormonal treatment, we describe a potential relationship between the progesterone agonist nomegestrol acetate (NOMAC) and meningioma growth.Methods: After implementation of a screening protocol to detect potential interactions between hormonal exposure and occurrence of meningioma, we identified patients taking NOMAC and newly diagnosed with a meningioma. NOMAC was stopped and those patients were followed tightly both clinically and radiologically. Retrospective volumetric analysis of the tumors was performed on the imaging.Results: Three patients were identified for the study. After cessation of the NOMAC, tumor shrinkage was documented for all meningiomas within the first month. Up to 70% of tumor volume reduction was observed during the first year of follow-up in one of them. None of the patients developed new symptoms.Conclusion: We report the first cases of meningiomas responsiveness to discontinuation of hormonal therapy with NOMAC. Similarly to cases associated with long-term CPA intake, tumor reduction, and improvement of clinical symptoms can be observed after cessation of NOMAC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACETATES
Subjects
Details
- Language :
- English
- ISSN :
- 00016268
- Volume :
- 161
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Acta Neurochirurgica
- Publication Type :
- Academic Journal
- Accession number :
- 135521779
- Full Text :
- https://doi.org/10.1007/s00701-019-03848-x