Synthesis, characterization, sustain delivery studies and anti-bacterial evaluation of β and γ -cyclodextrin core ciprofloxacin.

Aim: Structurally hybrid ciprofloxacin based sustain drug delivery systems were synthesized with biologically active β and γ-cyclodextrin. Cyclodextrin core ciprofloxacin based drug delivery systems have been synthesized with in two stages by reaction between ciprofloxacin, cyclodextrin and using chloroacetyl chloride as linking agent. Materials and methods: The sustain drug delivery were evaluated by various pH condition and the quantitative analysis of the ciprofloxacin drug formulations on different mode of drug release is monitored using ultraviolet spectrophotometer. Result and Discussion: The structures of the synthesised β-cyclodextrin giant molecules were characterized by means of MALDI-TOF, infrared, H1 and C13 NMR spectral studies. The results obtained undoubtedly evidenced that the drug ciprofloxacin release is pH dependant. Antibacterial performance of the spherical shaped macromolecule were investigated with Escherichia coli and staphylococcus bacteria and the cell viability reduced value of the designed β and γ-cyclodextrin core drug delivery system. The very long time active of drug is compared with standard ciprofloxacin. The in-vitro studies and ciprofloxacin discharge from the spherical shaped macromolecules were also investigated. Conclusion: Designed β and γ-cyclodextrin core drug delivery system is showing nearly five times higher bactericidal activity than the standard ciprofloxacin. [ABSTRACT FROM AUTHOR]