Back to Search Start Over

Lipase-catalyzed synthesis of ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods.

Authors :
Ding, Jing
Yang, Zhijun
Zhao, Yu
Fang, Weizhen
Lu, Qun
Source :
Bioscience, Biotechnology & Biochemistry. Apr2019, Vol. 83 Issue 4, p763-767. 5p.
Publication Year :
2019

Abstract

Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09168451
Volume :
83
Issue :
4
Database :
Academic Search Index
Journal :
Bioscience, Biotechnology & Biochemistry
Publication Type :
Academic Journal
Accession number :
135477053
Full Text :
https://doi.org/10.1080/09168451.2018.1554426