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Preclinical Studies of the Lemon Hill as a Multi-approach Antioxidant and Antidiabetic Plant: Citrus Pseudolimon Tanaka.
- Source :
-
Journal of Herbs, Spices & Medicinal Plants . 2019, Vol. 25 Issue 2, p69-87. 19p. - Publication Year :
- 2019
-
Abstract
- The antioxidant and antidiabetic activity of methanol leaves extract (CPMLE) and ethyl acetate fraction (CPEALF) of lemon hill (Citrus pseudolimon) was examined on key enzymes (α-glucosidase and α-amylase) in type-2 diabetes. In-vivo antidiabetic activity was evaluated in streptozotocin (STZ)-induced diabetic rats against CPMLE and CPEALF. Methanolic extract of the plant was effective against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (IC50 = 313.20 µg mL−1), reducing power (IC50 = 366.69 µg mL−1), and H2O2 scavenging (IC50 = 498.26 µg mL−1) and phosphomolybdate radical scavenging activity (IC50 = 508.02 µg mL−1). Ethyl acetate fraction demonstrated DPPH radical scavenging (IC50 = 259.33 µg mL−1), reducing power (IC50 = 268.91 µg mL−1), and H2O2 scavenging (IC50 = 476.39 µg mL−1) and phosphomolybdate radical scavenging activity (IC50 = 278.60 µg mL−1). C. pseudolimon methanol extract had inhibitory activity against α-glucosidase (IC50 = 350.09 µg mL−1) and α-amylase (IC50 = 291.17 µg mL−1) enzymes. Oral administration of CPMLE and CPEALF reduced elevated fasting blood glucose, lipid levels, and oxidative stress along with Hb1AC level. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINOGLYCOSIDES
*ANIMAL experimentation
*BLOOD sugar
*CALORIMETRY
*DIABETES
*DRUG design
*CLINICAL drug trials
*LEAVES
*LEMON
*LIPIDS
*METHANOL
*TYPE 2 diabetes
*ORAL drug administration
*RATS
*RESEARCH funding
*SPECTROPHOTOMETRY
*PLANT extracts
*OXIDATIVE stress
*IN vitro studies
*ONE-way analysis of variance
*IN vivo studies
Subjects
Details
- Language :
- English
- ISSN :
- 10496475
- Volume :
- 25
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Herbs, Spices & Medicinal Plants
- Publication Type :
- Academic Journal
- Accession number :
- 135461910
- Full Text :
- https://doi.org/10.1080/10496475.2019.1570994