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Role of the necrosis factor-κB pathway in dibutyl phthalate mediated effects on human glioma cells.
- Source :
-
Toxicological & Environmental Chemistry . May-Aug2018, Vol. 100 Issue 5-7, p644-657. 14p. - Publication Year :
- 2018
-
Abstract
- The human glioma cell line U251 was incubated for 12 h and 24 h in medium containing dibutyl phthalate at concentrations of 25 µmol/L and 100 µmol/L. Decreased cell viability and increased oxidative stress show the cytotoxicity of dibutyl phthalate. Nuclear factor-κB and nuclear factor-κB pathway-related proteins were altered, which could be attenuated by vitamin E at 20 µmol/L. Thus, dibutyl phthalate induces cytotoxicity through activation of nuclear factor-κB and vitamin E exerts neuroprotection against dibutyl phthalate-mediated cytotoxicity in vitro. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIBUTYL phthalate
*NECROSIS
*TUMOR necrosis factors
*VITAMIN E
*CELLS
Subjects
Details
- Language :
- English
- ISSN :
- 02772248
- Volume :
- 100
- Issue :
- 5-7
- Database :
- Academic Search Index
- Journal :
- Toxicological & Environmental Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 135415374
- Full Text :
- https://doi.org/10.1080/02772248.2019.1567732