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A New Formal Synthetic Route to Entecavir.
- Source :
-
Synlett . 2019, Vol. 30 Issue 6, p748-752. 5p. - Publication Year :
- 2019
-
Abstract
- We describe a new and straightforward approach to the formal synthesis of the hepatitis B virus inhibitor entecavir, an important hepatitis B drug, in ten steps overall. Key features of the route are a Morita–Baylis–Hillman reaction, a Sharpless asymmetric epoxidation, a reductive epoxide opening of an α,β-epoxy ketone, and a Riley selenium dioxide oxidation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BAYLIS-Hillman reaction
*HEPATITIS B virus
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 30
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 135405281
- Full Text :
- https://doi.org/10.1055/s-0037-1612215