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Escaping nuclear decay: the significance of mRNA export for gene expression.
- Source :
-
Current Genetics . Apr2019, Vol. 65 Issue 2, p473-476. 4p. - Publication Year :
- 2019
-
Abstract
- In this perspective, we discuss the regulatory impact of nuclear RNA export and decay on messenger RNA (mRNA) functionality. It is well established that control of protein-coding gene expression in eukaryotes employs the regulated production of mRNA, its intra-cellular transfer to cytoplasmic ribosomes and final transcript degradation. Despite a rich body of literature on these events, an involvement of nuclear RNA decay systems remains largely unexplored. Instead, nuclear RNA degradation is often considered a quality control precaution engaged primarily in ridding cells of aberrantly processed transcripts and spurious non-coding RNA. Recent research from human and budding yeast cells, however, demonstrates that even protein-coding transcripts fall prey to nuclear decay and that this is countered by their nuclear export. Here, we outline the potential of nuclear polyA-binding proteins in tuning levels of cellular mRNA to maintain transcript homeostasis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01728083
- Volume :
- 65
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Current Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 135395192
- Full Text :
- https://doi.org/10.1007/s00294-018-0913-x