Burden of Chagas disease in Brazil, 1990–2016: findings from the Global Burden of Disease Study 2016.

Graphical abstract Highlights • We present estimates of levels and trends of Chagas disease burden in Brazil from 1990 to 2016. • Chagas disease caused an estimated 141,640 DALYs (95% uncertainty interval: 129,065–155,941) in Brazil in 2016. • Age-standardized DALY rates due to Chagas disease showed a significant decreasing trend in Brazil over the period studied. • The highest DALY rates were observed among males, the elderly, and in states with important endemic areas in the past. • Chagas disease is still an important and neglected cause of health loss due to premature mortality and disability in Brazil. Abstract Chagas disease continues to be an important cause of morbidity, mortality and disability in several Latin American countries, including Brazil. Using findings from the Global Burden of Disease Study 2016 (GBD, 2016), we present years of life lost, years lived with disability, and disability-adjusted life years due to Chagas disease in Brazil, by sex, age group, and Brazilian states, from 1990 to 2016. Results are reported in absolute numbers and age-standardized rates (per 100,000 population) with 95% uncertainty intervals. In 2016, 141,640 disability-adjusted life years (95% uncertainty intervals: 129,065–155,941) due to Chagas disease were estimated in Brazil, with a relative reduction of 36.7% compared with 1990 (223,879 disability-adjusted life years (95% uncertainty intervals: 209,372–238,591)). Age-standardized disability-adjusted life year rates declined at the national level (−69.7%) and in all Brazilian states between 1990 and 2016, but with different regional patterns. The decrease in the disability-adjusted life year rates was driven primarily by a consistent reduction in the years of life lost rates, the main component of total disability-adjusted life years for Chagas disease. The highest fatal and non-fatal burden due to Chagas disease was observed among males, the elderly, and in those Brazilian states encompassing important endemic areas for vector transmission in the past. Despite the consistent reduction in its burden during the period, Chagas disease is still an important and neglected cause of health lost due to premature mortality and disability in Brazil. Efforts should be made to maintain the political interest and sustainability of surveillance and control actions for Chagas disease, prevent the risk of re-emergence of vector transmission in endemic areas, and provide health care to chronically infected individuals, including early diagnosis and treatment interventions. [ABSTRACT FROM AUTHOR]