Back to Search Start Over

An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households.

Authors :
Kamau, Everlyn
Onyango, Clayton O
Otieno, Grieven P
Kiyuka, Patience K
Agoti, Charles N
Medley, Graham F
Cane, Patricia A
Nokes, D James
Munywoki, Patrick K
Source :
Journal of Infectious Diseases. 3/15/2019, Vol. 219 Issue 6, p1049-1057. 9p.
Publication Year :
2019

Abstract

We report on infection patterns in 5 households (78 participants) delineating the natural history of human rhinovirus (HRV). Nasopharyngeal collections were obtained every 3-4 days irrespective of symptoms, over a 6-month period, with molecular screening for HRV and typing by sequencing VP4/VP2 junction. Overall, 311/3468 (8.9%) collections were HRV positive: 256 were classified into 3 species: 104 (40.6%) HRV-A; 14 (5.5%) HRV-B, and 138 (53.9%) HRV-C. Twenty-six known HRV types (13 HRV-A, 3 HRV-B, and 10 HRV-C) were identified (A75, C1, and C35 being most frequent). We observed continuous invasion and temporal clustering of HRV types in households (range 5-13 over 6 months). Intrahousehold transmission was independent of clinical status but influenced by age. Most (89.0%) of HRV infection episodes were limited to <14 days. Individual repeat infections were frequent (range 1-7 over 6 months), decreasing with age, and almost invariably heterotypic, indicative of lasting type-specific immunity and low cross-type protection. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00221899
Volume :
219
Issue :
6
Database :
Academic Search Index
Journal :
Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
135374735
Full Text :
https://doi.org/10.1093/infdis/jiy621