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Novel Triamcinolone Acetonide-Loaded Liposomes Topical Formulation for the Treatment of Cystoid Macular Edema After Cataract Surgery: A Pilot Study.
- Source :
-
Journal of Ocular Pharmacology & Therapeutics . Mar2019, Vol. 35 Issue 2, p106-115. 10p. - Publication Year :
- 2019
-
Abstract
- <bold>Purpose: </bold>To report tolerability, safety, and efficacy of a topical triamcinolone acetonide-loaded liposomes formulation (TA-LF) in targeting the macular area in patients with refractory pseudophakic cystoid macular edema (PCME).<bold>Methods: </bold>For tolerability, safety and efficacy evaluation, 12 eyes of 12 patients with refractory PCME were exposed to one drop of TA-LF (TA at 0.2%) every 2 h for 90 days or until best-corrected visual acuity (BCVA) was achieved. Intraocular pressure (IOP), slit lamp examination, and central foveal thickness (CFT) were analyzed at every visit.<bold>Results: </bold>Patients with refractory PCME under TA-LF therapy showed a significant improvement in BVCA and CFT without significant IOP modification (P = 0.94). On average CFT decreased to 206.75 ± 135.72 μm and BCVA improved to 20.08 ± 10.35 letters (P < 0.0005). BCVA was achieved at 10.58 ± 6.70 weeks (range 2-18). TA-LF was well tolerated in all cases. Neither ocular surface abnormalities nor adverse events were recorded.<bold>Conclusion: </bold>TA-LF was well tolerated and improved BCVA and CFT on patients with refractory PCME. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MACULA lutea
*LIPOSOMES
*CATARACT surgery
*EDEMA
*ANTI-inflammatory agents
*COMPARATIVE studies
*DRUG tolerance
*DOSAGE forms of drugs
*INJECTIONS
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*ARTIFICIAL membranes
*OPHTHALMIC drugs
*RESEARCH
*RETINAL degeneration
*TRIAMCINOLONE
*PILOT projects
*EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 10807683
- Volume :
- 35
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Ocular Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 135356695
- Full Text :
- https://doi.org/10.1089/jop.2018.0101