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Four-component, three-step cascade reaction: an effective synthesis of indazole-fused triazolo[5,1-c]quinoxalines.

Four-component, three-step cascade reaction: an effective synthesis of indazole-fused triazolo[5,1-c]quinoxalines.

Authors :
Shiva Kumar, K.
Naikawadi, Praveen Kumar
Rajesham, Bandari
Rambabu, D.
Source :
New Journal of Chemistry. 3/21/2019, Vol. 43 Issue 11, p4333-4337. 5p.
Publication Year :
2019

Abstract

An efficient four-component, three-step cascade reaction was developed for the synthesis of indazole-fused triazolo[5,1-c]quinoxalines from o-azido aldehyde, o-iodoaniline, phenylacetylene, and sodium azide. The methodology involves the sequential formation of 2H-indazole, then azide–alkyne cycloaddition, followed by C–N coupling, and finally intramolecular cross-dehydrogenative C–C coupling. Notable features of this protocol include simple starting materials, reduced synthetic steps, and good yields. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*SODIUM azide

Details

Language :
English
ISSN :
11440546
Volume :
43
Issue :
11
Database :
Academic Search Index
Journal :
New Journal of Chemistry
Publication Type :
Academic Journal
Accession number :
135233118
Full Text :
https://doi.org/10.1039/c8nj06299d