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A factor in the culture filtrate of some <em>Klebsiella</em> isolates specifically modifies the fibroblasts of HLA-B27-positive normal individuals.
- Source :
-
Immunology . Jun84, Vol. 52 Issue 2, p385-387. 3p. - Publication Year :
- 1984
-
Abstract
- Cultured skin fibroblasts of HLA-B27-positive clinically normal individuals specifically bind, and are modified by, a factor in the culture filtrate of some Klebsiella isolates. These modified fibroblasts are serologically similar to the cells (lymphocytes and fibroblasts) of B27-positive patients with anklosing sondylitis (B27+AS+ cells fail to bind the factor, presumably because a receptor present on B27+AS- cells has already been blocked or modified by a Klesiella antigen in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 52
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13517489