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Synthesis and antitumor activity of α-alkyliden-γ-lactones.
- Source :
-
International Journal of Pharmaceutical Research (09752366) . Oct-Dec2018, Vol. 10 Issue 4, p1-8. 8p. - Publication Year :
- 2018
-
Abstract
- The α-methylene-γ-butyrolactone skeleton is part of many natural products with remarkable biological properties. C75, a fatty acid synthase (FAS) inhibitor, is a synthetic α-methylene-γ-butyrolactone which is cytotoxic for different cell lines in vitro and in vivo against human cancer xenografts. We synthesized a panel of C75 derivatives through modifications of the a-methylene moiety at the C-ß/C-γ carbons of the γ-butyrolactone skeleton and tested their effects on different cancer models. The in vitro effects of the compounds on pancreatic, colon and breast cancer cell viability (PANC-1, HTC-116, Lovo, MCF-7, MDA-231-MB) were evaluated. Two compounds showed significant cytotoxicity. The structures of all synthesized compounds obtained were identified on the basis of their spectral data (IR, MS, NMR). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09752366
- Volume :
- 10
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Pharmaceutical Research (09752366)
- Publication Type :
- Academic Journal
- Accession number :
- 135154564
- Full Text :
- https://doi.org/10.31838/ijpr/2018.10.04.001