醒腦靜聯合古拉定對急性酒精中毒患者血清H2O2、SOD、MDA及iNOS水平的影響.

Objective: To explore the clinical effect of Xingnaojing combined with Gluthion on the acute alcoholism and influence on the levels of serum hydrogen peroxide（H2O2）, superoxide dismutase（SOD）, malonaldehyde（MDA）, and inducible nitric oxide synthase（i NOS）. Methods: 80 cases of patients with acute alcoholism admitted in our hospital from April 2015 to April 2017 were selected and randomly divided into two groups. 40 patients from the control group were treated with Xingnaojing, while the other 40 patients from the observation group were administrated with a combination of Xingnaojing and Gluthion. The time for improvement in symptoms, the liver function and changes of serological indicators before and after treatment, the clinical effect, and the incidence of adverse reactions were compared between the two groups. Results: The time to resume normal blood pressure, heart rate and consciousness of observation group were significantly shorter than those of the control group（P<0.01）. The gamma-glutamyl transpeptidase（GGT）, aspartate transaminase（AST）, and alanine transaminase（ALT） levels in both groups were evidently decreased as compared with those before treatment,and the above indexes in observation group were significantly lower than those in control group（P<0.01）. For both groups, at 4, 8 h after treatment, the levels of H2O2, MDA and i NOS were dipped（P<0.01） and that of SOD jumped（P<0.01）, and the improvement in the observation group was larger than that in the control group（P<0.01）. The overall effective rate of observation group reached 97.50% which was slightly higher than 90.00% of the control group, but showed no statistical difference（P>0.05）. The proportion of patients feeling uncomfortable after waking up was 27.5% in the observation group, which was much lower than 67.5% in the control group（P<0.01）.Conclusion: Xingnaojing and Gluthion has better a clinical effect in treating patients with acute alcoholism by eliminating patients symptoms in a faster manner, improving their liver function and reducing their discomfor, which may be associated with its effect in reducing patients’ serum MDA and i NOS lelves, and increasing their SOD levels as well. [ABSTRACT FROM AUTHOR]