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Ameliorative Effect of WithaferinA on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat.
- Source :
-
Pharmacology . Apr2019, Vol. 103 Issue 3/4, p114-119. 6p. 3 Graphs. - Publication Year :
- 2019
-
Abstract
- Withaferin A (WA) was evaluated for its neuro-protective efficacy on ageing induced striatal dopamine (DA) and behavioural changes in aged rats. Wistar albino rats were divided into group I – young (3 months), Group II – aged (24 months), Group III – aged rats supplemented with WA (50 mg/kg b.w once in a day for 30 days) and Group IV – young rats supplemented with WA (50 mg/kg b.w). The HPLC assay revealed significant decline in the levels of DA and homovanillic acid (HVA) in substantia nigra (SN) and striatum (ST) of aged rat. A marked decline in motor activity of aged rat was observed through open field, beam walking and grid walking motor experiments. These results indicate that ageing reduces nigro-striatal activity as well as nigro-striatal DA levels. Interestingly, the administration of WA (50 mg\kg b.w) resulted in a substantial resurge of DA and HVA in SN and ST and a significant reversal of motor impairment in aged rats. This study is the first report that evidently determines the neuro-protective efficacy of WA on dopaminergic system of SN and ST in aged rats. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00317012
- Volume :
- 103
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 135036830
- Full Text :
- https://doi.org/10.1159/000495510