Ameliorative effect of salidroside from Rhodiola Rosea L. on the gut microbiota subject to furan-induced liver injury in a mouse model.

Abstract In our study, the ameliorative effect of salidroside (SAL) from Rhodiola Rosea L. on the intestinal microflora subject to furan-induced liver injury in a mouse model was investigated by 16 S rDNA, oxidative indexes, LPS and cytokine levels. The results demonstrated that SAL alleviated hepatic oxidative injury by inhibiting the activities of AST, ALT and the content of MDA, and promoting the activities of SOD, GSH and GST, compared to the furan-treated group. SAL significantly modified the intestinal microbial diversity and downregulated the circulating levels of serum LPS, IL-6, and TNF-α, as well as enhanced the content of IL-10. Importantly, SAL dramatically increased LPS-suppressing bacteria genera Akkermansia, and decreased LPS-producing bacteria phyla Proteobacteria. Our results indicate that SAL supplement restrains intestinal microbial dysbiosis and systemic low-grade inflammation induced by furan. Hopefully, SAL is a potential therapeutical and prophylactic compound in medicament for hepatic diseases. Graphical abstract SAL play an ameliorative role to improve liver diseases by affecting gut microbiota in furan-induced mice using 16 S rDNA sequencing. Image 1 Highlights • The ameliorative effect of SAL on gut microflora subject to furan-induced liver injury was investigated by 16 S rDNA. • SAL dramatically increased LPS-suppressing bacteria Akkermansia , and decreased LPS-producing bacteria Proteobacteria. • SAL supplement restrained intestinal microbial dysbiosis and systemic low-grade inflammation induced by furan. [ABSTRACT FROM AUTHOR]