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Overexpression of the Interferon-Inducible Isoform 4 of NCOA7 Dissects the Entry Route of Enveloped Viruses and Demonstrates that HIV Enters Cells via Fusion at the Plasma Membrane.
- Source :
-
Viruses (1999-4915) . Feb2019, Vol. 11 Issue 2, p121. 1p. - Publication Year :
- 2019
-
Abstract
- The HIV-1 entry-route is a matter of ongoing controversy, and there is evidence for fusion either at the cell surface or from within endosomes. A recent report demonstrated that isoform 4 of nuclear receptor coactivator 7 (NCOA7iso4) interacts with endolysosomal vacuolar-type H+-ATPase (V-ATPase), increasing lytic activity and thereby severely affecting the entry of vesicular stomatitis virus glycoprotein (VSV-G)-mediated, but not HIV-Env-mediated, entry and infection. As basal expression of NCOA7iso4 is low in the absence of type-1 interferons, its overexpression is a novel tool to study viral entry. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL membranes
*INTERFERONS
*GLYCOPROTEINS
*VESICULAR stomatitis
*LYTIC cycle
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 11
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Viruses (1999-4915)
- Publication Type :
- Academic Journal
- Accession number :
- 134963623
- Full Text :
- https://doi.org/10.3390/v11020121