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α -Tetralonyl Glucosides from the Green Walnut Husks of Juglans mandshurica and Their Antiproliferative Effects.

α -Tetralonyl Glucosides from the Green Walnut Husks of Juglans mandshurica and Their Antiproliferative Effects.

Authors :
Wang, An-dong
Xie, Chao-jie
Zhang, Yun-qiang
Li, Mei-chen
Wang, Xia
Liu, Jian-yu
Xu, Yong-nan
Source :
Planta Medica. 2019, Vol. 85 Issue 4, p335-339. 5p.
Publication Year :
2019

Abstract

Two new α -tetralonyl glucosides, (4 S)-4,5,8-trihydroxy- α -tetralone-5- O - β -D-glucopyranosyl(1 → 6)- β -D-glucopyranoside (1) and (4 S)-4,8-dihydroxy- α -tetralone-4- O - β -D-glucopyranosyl(1 → 6)- β -D-glucopyranoside (2), together with eight known compounds (3 – 10) were isolated from the green walnut husks of Juglans mandshurica. The structural characterization of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS experiments. The isolated compounds were assayed for their cytotoxicity against two human cancer cell lines, A549 and HeLa. Four compounds (7 – 10) exhibited inhibitory effects against two human cancer cell lines with GI50 values between 1.3 and 5.8 µM. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00320943
Volume :
85
Issue :
4
Database :
Academic Search Index
Journal :
Planta Medica
Publication Type :
Periodical
Accession number :
134933323
Full Text :
https://doi.org/10.1055/a-0832-2328