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Extracellular Histones Promote Pulmonary Fibrosis in Patients With Coal Workers' Pneumoconiosis.
- Source :
-
Journal of Occupational & Environmental Medicine . Feb2019, Vol. 61 Issue 2, p89-95. 7p. - Publication Year :
- 2019
-
Abstract
- Objective: This investigation assessed the profibrotic role that extracellular histones play in the pathogenesis of coal workers' pneumoconiosis (CWP). Methods: The correlation of extracellular histones with small opacity profusion (SOP) and transforming growth factor-ß (TGF-ß) was analyzed. The stimulating effect of extracellular histones on pulmonary fibroblast was assessed in vitro. Results: The levels of extracellular histones in plasma were positively correlated with SOP and TGF-ß in the coal miners investigated. Plasma collected from patients with CWP caused apparent lung fibroblast proliferation, while anti-H4 antibody antagonized the stimulating effect of the patient plasma by blocking histone H4. In vitro experiments showed that extracellular histones directly stimulated fibroblast proliferation. Conclusion: Consistent with our hypothesis, the concentrations of extracellular histones were indices of the severity of pulmonary fibrosis in simple CWP, and extracellular histones-targeted Intervention could inhibit the proliferation of lung fibroblast. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10762752
- Volume :
- 61
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Occupational & Environmental Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 134863397
- Full Text :
- https://doi.org/10.1097/JOM.0000000000001473