The effects of Bisphenol A (BPA) on sympathetic nerve fibers in the uterine wall of the domestic pig.

Highlights • The number of DBH-positive fibers and their neurochemical characterization in the uterine of the control animals and pigs treated of bisphenol A. • Bisphenol A coused changes in neurochemichal characterization in the uterine in a both: low and high dose treated. • The most visable changes was observed in case of DBH/VIP-positive fiber after a high dose treated of bisphenol A. Abstract Bisphenol A (BPA), used in the production of plastic, shows multidirectional negative effects on the living organism. BPA may affect the reproductive and nervous systems; however, its influence on the nerves supplying the uterus has not been studied. During the present study, the impact of BPA on the sympathetic nerves in the uterus was investigated using a double immunofluorescence technique. The results have shown that even low doses of BPA may change the neurochemical characterization of uterine sympathetic nerves, and the severity of these changes depends on the part of the uterus and the dose of the toxic substance. Probably the changes observed during the present study resulted from the neurotoxic and/or pro-inflammatory activity of BPA, but the exact mechanism for the observed fluctuation still remains unknown. The fluctuations of the neurochemical characterization of the uterine intramural nerves may be the first subclinical signs of harmful exposure to BPA. [ABSTRACT FROM AUTHOR]