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Diurnal variation of metabolites in three individual participants.
- Source :
-
Chronobiology International: The Journal of Biological & Medical Rhythm Research . Mar2019, Vol. 36 Issue 3, p332-342. 11p. 4 Charts, 3 Graphs. - Publication Year :
- 2019
-
Abstract
- The circadian system influences virtually all biological functions. Understanding the impact of circadian variation on metabolism may provide insight into mechanisms of circadian-associated disorders and guide the implementation of chrono-therapy. Previous research has reported circadian variation in 7-20% of metabolites in human blood. In this study, untargeted metabolomics profiles were measured using blood of two healthy men and one healthy woman, collected every 2 h for up to 48 h under carefully controlled conditions. The pattern of variation of each metabolite over time was examined on each participant separately, using both one- and two-order harmonic models. A total of 100 of 663 metabolites, representing all metabolite categories, showed diurnal rhythmic concentrations that exceeded the Bonferroni threshold (P < 2.5 × 10−5). Overall, peak times of many metabolites were clustered during the afternoon-midnight, including the majority of amino acids, all peptides, all lysolipids and all phospholipids, whereas the majority of steroids peaked in the morning. We observed substantial inter-individual variation for both peak times and amplitudes in these three subjects. In conclusion, at least 15% of blood metabolites, representing a broad group of biological pathways, exhibit diurnal variation in three participants. The average peak times of most of these metabolites are clustered in morning or afternoon-midnight. Further work is needed to validate and extend this work in more individuals. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07420528
- Volume :
- 36
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Chronobiology International: The Journal of Biological & Medical Rhythm Research
- Publication Type :
- Academic Journal
- Accession number :
- 134749282
- Full Text :
- https://doi.org/10.1080/07420528.2018.1541901