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Characterization of newly emerged NADC30-like strains of porcine reproductive and respiratory syndrome virus in China.

Authors :
Zhang, Hongliang
Leng, Chaoliang
Ding, Yushan
Zhai, Hongyue
Li, Zhen
Xiang, Lirun
Zhang, Wenli
Liu, Chunxiao
Li, Minhua
Chen, Jiazeng
Bai, Yun
Kan, Yunchao
Yao, Lunguang
Peng, Jinmei
Wang, Qian
Tang, Yan-Dong
An, Tongqing
Cai, Xuehui
Tian, Zhijun
Tong, Guangzhi
Source :
Archives of Virology. Feb2019, Vol. 164 Issue 2, p401-411. 11p.
Publication Year :
2019

Abstract

Different strains of porcine reproductive and respiratory syndrome virus (PRRSV) have emerged and circulated in different regions of mainland China since 1996, particularly after 2006. In 2012, NADC30-like PRRSV was first isolated in Henan Province. By 2016, it had spread to most provinces in China. In the present study, the whole genomes (excluding the poly(A) tails) of 13 newly emerged NADC30-like PRRSV strains were sequenced and analyzed. Furthermore, the pathogenicity of SD53-1603, one of the 13 PRRSV strains, was assessed. Phylogenetic analysis showed that these 13 newly emerged NADC30-like PRRSV strains, together with some reference strains, formed a new subgroup (subgroup 5), characterized by a predicted 131-amino-acid deletion in the nonstructural protein (NSP) 2. However, low levels of whole-genome similarity and a wide variety of recombination patterns complicated the classification of the NADC30-like PRRSV isolates. Interestingly, almost all of the recombination breakpoints found in these 13 PRRSV isolates and other NADC30-like PRRSV isolates occurred in genes encoding NSPs and/or minor structural proteins. In addition, piglets infected with the newly emerged NADC30-like strain SD53-1603 displayed clear clinical respiratory symptoms and underwent typical pathological changes. The findings may be useful for elucidating the characteristics and epidemic status of NADC30-like PRRSV in China. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03048608
Volume :
164
Issue :
2
Database :
Academic Search Index
Journal :
Archives of Virology
Publication Type :
Academic Journal
Accession number :
134622814
Full Text :
https://doi.org/10.1007/s00705-018-4080-7