Back to Search
Start Over
Clemochinenosides C and D, two new macrocyclic glucosides from Clematis chinensis.
- Source :
-
Journal of Asian Natural Products Research . Nov2018, Vol. 20 Issue 11, p1038-1044. 7p. - Publication Year :
- 2018
-
Abstract
- The EtOH extract of the roots and rhizomes of Clematis chinensis afforded two new macrocyclic glucosides clemochinenosides C (1) and D (2). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. These compounds were evaluated for inhibitory activity against lipopolysaccharides-induced TNF-α production in RAW 246.7 macrophages. Compounds 1 and 2 showed moderate inhibitory activity with IC50 values of 12.9 ± 2.3 and 18.4 ± 2.7 μM, respectively. In addition, a proliferation study was used to evaluate the anti-angiogenic effects of these compounds in vitro (VEGF-induced human umbilical vein endothelial cell proliferation). Compounds 1 and 2 displayed weak inhibitory effects with inhibition rates of 26.3 ± 1.8 and 19.2 ± 2.6% at 50 μM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL proliferation
*CELL lines
*PHYSICAL & theoretical chemistry
*EPITHELIAL cells
*GLYCOSIDES
*HETEROCYCLIC compounds
*HIGH performance liquid chromatography
*MACROPHAGES
*MEDICINAL plants
*MOLECULAR structure
*PROTON magnetic resonance spectroscopy
*RESEARCH funding
*PLANT roots
*TERPENES
*TOXICITY testing
*PHYTOCHEMICALS
*PLANT extracts
*VASCULAR endothelial growth factors
*LIPOPOLYSACCHARIDES
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 20
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 134622382
- Full Text :
- https://doi.org/10.1080/10286020.2017.1387780