IgG4 相关性疾病（IgG4-RD)发病机制的研究进展.

IgG4-related disease (IgG4-RD) is a kind of autoimmune disease which is characterized by multi-organomegaly and elevated serum IgG4. Till now, the pathogenesis of IgG4-RD is unknown. The pattern recognition receptor of antigen-presenting cell is activated by pathogen infection, then CD4+ T cell is activated by antigen presentation and transform into Th1, Th2, Treg and Tfh cell. The cytokines secreted by Th1, Th2, Treg and Tfh cell will promote the activation of B cells and transformation to plasma cells and production of IgG4. Futhermore, transforming growth factor β (TGF-β) and platelet-derived growth factor secreted by macrophage and Treg will promote the fibrosis. The above cytokines and immune cells play important roles in the pathogenesis of IgG4-RD, which provide new strategy for treatment in the future. [ABSTRACT FROM AUTHOR]