Asymmetric Synthesis of cis-5-(Aminomethyl)-3-(4-methoxyphenyl) dihydrofuran-2(3H)-one.

The asymmetric synthesis of (3R,5S)-5-(aminomethyl)-3-(4- methoxyphenyl)dihydrofuran-2(3H)-one, as the most potent selective inactivator of monoamine B, was successfully achieved by applying a newly developed synthetic method toward the key γ-aminomethyl-γ- lactone via intramolecular aziridine ring opening in 63% overall yield from a commercial starting material. [ABSTRACT FROM AUTHOR]