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Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence.

Authors :
Kumar, Ashok
Foster, Thomas C.
Source :
Neurochemical Research. Jan2019, Vol. 44 Issue 1, p38-48. 11p.
Publication Year :
2019

Abstract

Glutamate is the primary excitatory neurotransmitter in neurons and glia. N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate receptors are major ionotropic glutamate receptors. Glutamatergic neurotransmission is strongly linked with Ca2+ homeostasis. Research has provided ample evidence that brain aging is associated with altered glutamatergic neurotransmission and Ca2+ dysregulation. Much of the work has focused on the hippocampus, a brain region critically involved in learning and memory, which is particularly susceptible to dysfunction during senescence. The current review examines Ca2+ regulation with a focus on the NMDA receptors in the hippocampus. Integrating the knowledge of the complexity of age-related alterations in Ca2+ homeostasis and NMDA receptor-mediated glutamatergic neurotransmission will positively shape the development of highly effective therapeutics to treat brain disorders including cognitive impairment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03643190
Volume :
44
Issue :
1
Database :
Academic Search Index
Journal :
Neurochemical Research
Publication Type :
Academic Journal
Accession number :
134281061
Full Text :
https://doi.org/10.1007/s11064-018-2634-4