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Antifungal activity, DNA and lysozyme binding affinity of Pd(II) and Pt(II) complexes bearing N,N-pyridylbenzimidazole ligand.
- Source :
-
Journal of Coordination Chemistry . Oct2018, Vol. 71 Issue 20, p3381-3391. 11p. 1 Diagram, 4 Graphs. - Publication Year :
- 2018
-
Abstract
- The lysozyme- and DNA-binding affinities of the biologically active cisplatin analogues, Pd(II) (1) and Pt(II) (2) complexes of functionalized N,N-pyridylbenzimidazole ligand, are reported. The electronic transitions were studied by time-dependent density functional theory. Complex 1 exhibits interesting antifungal activity against Candida albicans (MIC = 32 μg mL−1; 64 nM) and Cryptococcus neoformans (MIC = 16 μg mL−1, 32 nM). Complex 1 is covalently bound to DNA and lysozyme via the elimination of the chloride ligand(s). When complex 2 interacts with lysozyme, two adduct peaks are observed in the mass spectrum corresponding to binding of Pt(II) ion to lysozyme. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00958972
- Volume :
- 71
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Journal of Coordination Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 134265722
- Full Text :
- https://doi.org/10.1080/00958972.2018.1517256