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Simvastatin delivery on PEEK for bioactivity and osteogenesis enhancements.

Authors :
Deng, Li-Jun
Wu, Yan-Lin
He, Xian-Hua
Xie, Ke-Nan
Xie, Lu
Deng, Yi
Source :
Journal of Biomaterials Science -- Polymer Edition. Dec2018, Vol. 29 Issue 18, p2237-2251. 15p. 3 Diagrams, 4 Graphs.
Publication Year :
2018

Abstract

A strategy developed for obtaining positive cellular responses remains to be focused in the filed of functional biomimetics. In this study, a hydrogel covered simvastatin-loaded polyetheretherketone (PEEK) bio-composites was constructed with the purpose of bone tissue regeneration therapy. Briefly, a three-dimensional (3D) porous structure was fabricated on PEEK surface; then the substrate was functionalized with the poly(L-lactic acid)/simvastatin porous film and hyaluronic acid hydrogel subsequently. In vitro cell attachment, proliferation, and cytoskeletal observation experiments reveal that our scaffolds show better bio-affinity due to the layer of hyaluronic acid hydrogel compared with control. Furthermore, the alkaline phosphatase activity, calcium mineral deposition evaluation, and gene expression for osteogenic potential all exhibit that the superior osteogenic differentiation of MC3T3-E1 pre-osteoblasts on our scaffolds. Therefore, our PEEK samples loaded with simvastatin and covered with hyaluronic acid hydrogel hold great potential in clinical applications for bone repair. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09205063
Volume :
29
Issue :
18
Database :
Academic Search Index
Journal :
Journal of Biomaterials Science -- Polymer Edition
Publication Type :
Academic Journal
Accession number :
134238088
Full Text :
https://doi.org/10.1080/09205063.2018.1534668