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Organoruthenium(ii) nucleoside conjugates as colon cytotoxic agents.
- Source :
-
New Journal of Chemistry . 1/21/2019, Vol. 43 Issue 3, p1195-1201. 7p. - Publication Year :
- 2019
-
Abstract
- Eleven ruthenium-nucleoside conjugates with the general formula [(η5-C5H5)Ru(PP)L][PF6] (PP = 1,2-bis(diphenylphosphino)ethane (Dppe), 2PPh3, and L = 3-N-(p-cyanobenzyl)thymidine derivative ligand) are reported. Both [(η5-C5H5)Ru(Dppe)N≡C-R]+ and [(η5-C5H5)Ru(PPh3)2N≡C-R]+ scaffolds exhibit remarkable stability towards hydrolysis. Compounds show high cytotoxicity in HCT116 colon cancer cells, with IC50 values down to 1.0 μM. Uptake competition experiments with 2′-deoxyadenosine revealed its cellular absorption to be independent of nucleoside transporters. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ORGANORUTHENIUM compounds
*NUCLEOSIDES
*COLON cancer
Subjects
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 43
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 134134788
- Full Text :
- https://doi.org/10.1039/c8nj04515a