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Tocilizumab prevents renal function of a patient with diabetic kidney disease: case report.
- Source :
-
Modern Rheumatology Case Reports . Jan2019, Vol. 3 Issue 1, p53-56. 4p. - Publication Year :
- 2019
-
Abstract
- Diabetic kidney disease (DKD) is the major cause of end stage renal disease. Despite the best current treatment, it is difficult to stop the progression of DKD. We report a 77-year-old Japanese man in whom rheumatoid arthritis (RA) was diagnosed at the age of 30 years, followed by type 2 diabetes mellitus (T2DM) at age 55. His haemoglobin A1c (HbA1c) was around 7-9%, even after starting insulin therapy. His renal function deteriorated steadily, with the estimated glomerular filtration rate (eGFR) decreasing by 2 mL/min/1.73 m2 per year to reach 29 mL/min/1.73 m2 (consistent with stage IV diabetic kidney disease) at age 69. Because RA was poor controlled with a DAS28-ESR of 4.46, HAQ of 0.375, and SDAI of 8.6, treatment with tocilizumab (an interleukin-6 receptor antibody) was initiated. Thereafter, control of RA improved, but HbA1c stayed in the range of 7-9%. However, eGFR remained around 30 ml/min/1.73 m2 even after 8 years. This case indicates that interleukin-6 might contribute to exacerbation of renal dysfunction, since IL-6 receptor blockade prevented deterioration of renal function in this patient with RA and diabetic kidney disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 24725625
- Volume :
- 3
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Modern Rheumatology Case Reports
- Publication Type :
- Academic Journal
- Accession number :
- 133982328
- Full Text :
- https://doi.org/10.1080/24725625.2018.1477489