Efecto de la combinación de un antisuero y el extracto etanólico de Randia aculeata (Crucetillo) contra el daño pulmonar que provoca el veneno de Bothrops asper.

When a person is bitten by a venomous snake he orshe needs to get medical attention as quick as possible. Damage caused by the poison from certain species can be irreversible, mostly in cases where necrosis is found. In this cases it is possible the patient can lose the affected extremity since the venomis rapidly propagated in tissue. Currently, new alternatives are being researched to control or delay the effect of venom. This could allow time enough for the person to be taken care of with the corresponding serum. Poisoning by snake bite is very common in Mexico and it represents a serious public health problem. The most common case of this is by the Bothrops asper species mainly in the southeast part of the country. The usual treatment against this is the administration of polyvalent serum which is considered as the most effective treatment. However, the use of extract of the Randia aculeata plant has been proven to be also effective as a anti-ophidian treatment against the venom making the patient go through a faster recovery thus, avoiding medical complications common in this kind of patients. Anintoxication of male mice of the CD1 strain was made. We had 4 groups: a) Control: administered with saline solution (s.s), b) Intoxicated with B. asper venom, c) b) Intoxicated with B. asper venom + faboterapico, b) Intoxicated with B. asper venom + faboterapico + ethanolic extract of R. aculeata. After 24 hours lungs were extracted and, after an histological technique, were observed by microscope. Micro photographs were taken and histological damage was evaluated. Relative lung weight was also obtained. The venom provoked necrosis, edema butal so several leukocytes were found which were protected by the faboterapico. R. aculeata helps to get this protective effect. [ABSTRACT FROM AUTHOR]