Diastereomer Assignment of an Olefin-Linked Bis-paracyclophane by Ion Mobility Mass Spectrometry.

The combination of ion mobility, mass spectrometry and molecular mechanics calculations provides a powerful method for diastereomer determination. Information about the olefinic linkage connectivity was obtained using ion mobility experiments and molecular mechanics calculations. In the ion mobility experiments, sodiated ions of trans-1,2-bis([2,2]paracyclophanyl)ethene, formed by MALDI, are mass selected and injected at low energy into a drift cell. The ions are rapidly thermalized by collisions with the helium gas and travel through the drift cell under the influence of a weak electric field.