Back to Search
Start Over
Sentinels at the wall: epithelial‐derived cytokines serve as triggers of upper airway type 2 inflammation.
- Source :
-
International Forum of Allergy & Rhinology . Jan2019, Vol. 9 Issue 1, p93-99. 7p. - Publication Year :
- 2019
-
Abstract
- Recent evidence has demonstrated an expanding role of respiratory epithelial cells in immune surveillance and modulation. Studies have been focusing on the earliest events that link epithelial injury to downstream inflammatory responses. Cytokines produced by and released from respiratory epithelial cells are among these early trigger signals. Epithelial‐derived cytokines, namely thymic stromal lymphopoietin (TSLP), interleukin (IL)‐25, and IL‐33, have come to the forefront of recent investigations. Each of these 3 cytokines has been implicated in chronic rhinosinusitis (CRS), asthma, and atopy. Herein we review studies elucidating the roles of epithelial‐derived cytokines in the pathobiology of upper airway disease, with particular emphasis on type 2 inflammatory conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THYMIC stromal lymphopoietin
*IMMUNOREGULATION
*SINUSITIS
*ASTHMA
Subjects
Details
- Language :
- English
- ISSN :
- 20426976
- Volume :
- 9
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Forum of Allergy & Rhinology
- Publication Type :
- Academic Journal
- Accession number :
- 133893838
- Full Text :
- https://doi.org/10.1002/alr.22206