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Anti-hyperlipidaemic assay and LC-MS/MS determination of piperinic ester in rat.
- Source :
-
Journal of Chinese Pharmaceutical Sciences . Dec2018, Vol. 27 Issue 12, p840-846. 7p. - Publication Year :
- 2018
-
Abstract
- In the present study, we aimed to establish high-fat diet model for evaluating anti-hyperlipidaemic activity of GBA and to establish the HPLC-MS method for measuring the pharmacokinetics of GBA in rat blood plasma and liver after oral administration. Rats were orally administrated with GBA at the dose of 50 mg/kg body weight. GBA concentrations in blood plasma and liver were detected by HPLC from 0.5–10 h post administrations. The pharmacokinetic parameters were analyzed by the DAS 1.0 Software. The concentration-time curves of the plasma GBA and liver GBA were conformed to two-compartment model. GBA was rapidly absorbed in the gastrointestinal tract and could be detected in plasma and liver 0.5 h after oral administration. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10031057
- Volume :
- 27
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Chinese Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 133805064
- Full Text :
- https://doi.org/10.5246/jcps.2018.12.085