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Clinical and demographic features of chronic progressive external ophthalmoplegia in a large adult-onset cohort.
- Source :
-
Mitochondrion . Jan2019, Vol. 44, p15-19. 5p. - Publication Year :
- 2019
-
Abstract
- Abstract Chronic progressive external ophthalmoplegia (CPEO) is a common mitochondrial disease. We evaluated the impact of sex and smoking status upon knee extension strength and the phenotypic spectrum of disease in a large cohort of adult-onset CPEO patients (N = 116) using retrospective chart analysis. The CPEO patients showed significantly lower knee extension strength as compared to the age- and sex-matched control population (− 37%, P < 0.05). Smoking also negatively impacted knee extension strength only in women with CPEO (− 26%, P < 0.05). We conclude that smoking and female sex interact negatively in CPEO patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15677249
- Volume :
- 44
- Database :
- Academic Search Index
- Journal :
- Mitochondrion
- Publication Type :
- Academic Journal
- Accession number :
- 133750818
- Full Text :
- https://doi.org/10.1016/j.mito.2017.12.006