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Antioxidants Facilitate High-intensity Exercise IL-15 Expression in Skeletal Muscle.

Antioxidants Facilitate High-intensity Exercise IL-15 Expression in Skeletal Muscle.

Authors :
Pérez-López, Alberto
Martin-Rincon, Marcos
Santana, Alfredo
Perez-Suarez, Ismael
Dorado, Cecilia
Calbet, Jose A. L.
Morales-Alamo, David
Source :
International Journal of Sports Medicine. 2019, Vol. 40 Issue 1, p16-22. 7p.
Publication Year :
2019

Abstract

Interleukin (IL)-15 stimulates mitochondrial biogenesis, fat oxidation, glucose uptake and myogenesis in skeletal muscle. However, the mechanisms by which exercise triggers IL-15 expression remain to be elucidated in humans. This study aimed at determining whether high-intensity exercise and exercise-induced RONS stimulate IL-15/IL-15Rα expression and its signaling pathway (STAT3) in human skeletal muscle. Nine volunteers performed a 30-s Wingate test in normoxia and hypoxia (PIO2 = 75 mmHg), 2 h after placebo or antioxidant administration (α-lipoic acid, vitamin C and E) in a randomized double-blind design. Blood samples and muscle biopsies (vastus lateralis) were obtained before, immediately after, and 30 and 120 min post-exercise. Sprint exercise upregulated skeletal muscle IL-15 protein expression (ANOVA, P = 0.05), an effect accentuated by antioxidant administration in hypoxia (ANOVA, P = 0.022). In antioxidant conditions, the increased IL-15 expression at 120 min post-exercise (33 %; P = 0.017) was associated with the oxygen deficit caused by the sprint (r = -0.54; P = 0.020); while, IL-15 and Tyr705-STAT3 AUCs were also related (r = 0.50; P = 0.036). Antioxidant administration promotes IL-15 protein expression in human skeletal muscle after sprint exercise, particularly in severe acute hypoxia. Therefore, during intense muscle contraction, a reduced PO2 and glycolytic rate, and possibly, an attenuated RONS generation may facilitate IL-15 production, accompanied by STAT3 activation, in a process that does not require AMPK phosphorylation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01724622
Volume :
40
Issue :
1
Database :
Academic Search Index
Journal :
International Journal of Sports Medicine
Publication Type :
Academic Journal
Accession number :
133682606
Full Text :
https://doi.org/10.1055/a-0781-2527