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Electroencephalogram dynamics during general anesthesia predict the later incidence and duration of burst-suppression during cardiopulmonary bypass.
- Source :
-
Clinical Neurophysiology . Jan2019, Vol. 130 Issue 1, p55-60. 6p. - Publication Year :
- 2019
-
Abstract
- Highlights • Intraoperative electroencephalogram burst-suppression is associated with post-operative delirium. • Decreased alpha and beta power was evident in the EEG prior to the occurrence of burst-suppression. • Decreased EEG alpha and beta power predicted the later incidence and duration of burst-suppression. Abstract Objective Electroencephalogram burst-suppression during general anesthesia is associated with post-operative delirium (POD). Whether burst-suppression causes POD or merely reflects susceptibility to POD is unclear. We hypothesized decreased intraoperative alpha (8–12 Hz) and beta (13–33 Hz) power prior to the occurrence of burst-suppression in susceptible patients. Methods We analyzed intraoperative electroencephalogram data of cardiac surgical patients undergoing cardiopulmonary bypass (CPB). We detected the incidence and duration of CPB burst-suppression with an automated burst-suppression detection algorithm. We analyzed EEG data with multitaper spectral estimation methods. We assessed associations between patient characteristics and burst-suppression using Binomial and Zero-inflated Poisson Regression Models. Results We found significantly decreased alpha and beta power (7.8–22.95 Hz) in the CPB burst-suppression cohort. The odds ratio for the association between point estimates for alpha and beta power (7.8–22.95 Hz) and the incidence of burst-suppression was 0.88 (95% CI: 0.79–0.98). The incidence rate ratio for the association between point estimates for power between the alpha and beta range and the duration of burst-suppression was 0.89 (95% CI: 0.84–0.93). Conclusion Decreased intra-operative power within the alpha and beta range was associated with susceptibility to burst-suppression during CPB. Significance This dynamic may be used to develop principled neurophysiological-based approaches to aid the preemptive identification and targeted care of POD vulnerable patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13882457
- Volume :
- 130
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 133665592
- Full Text :
- https://doi.org/10.1016/j.clinph.2018.11.003