Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms.

Highlights • Microorganisms are a prolific source of highly bioactive compounds. • Omics approaches to unveil biosynthetic gene clusters encoding new natural product. • Use multi-omics tools to study the regulation of natural products biosynthesis. Natural products produced by microorganisms represent the main source of bioactive molecules. The development of high-throughput (omics) techniques have importantly contributed to the renaissance of new antibiotic discovery increasing our understanding of complex mechanisms controlling the expression of biosynthetic gene clusters (BGCs) encoding secondary metabolites. In this context this review highlights recent progress in the use and integration of 'omics' approaches with focuses on genomics, transcriptomics, proteomics metabolomics meta-omics and combined omics as powerful strategy to discover new antibiotics. [ABSTRACT FROM AUTHOR]