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PPARδ agonist enhances colitis-associated colorectal cancer.
- Source :
-
European Journal of Pharmacology . Jan2019, Vol. 842, p248-254. 7p. - Publication Year :
- 2019
-
Abstract
- Abstract As a nuclear receptor, peroxisome proliferator-activated receptor-δ (PPARδ) plays a critical role in regulating inflammation and cancer, while it is still unclear the mechanism of PPARδ agonist GW501516 on colitis-associated colorectal cancer. Here we found that GW501516 significantly enhanced colitis-associated colorectal cancer in AOM/DSS-induced mice. In addition, PPARδ agonist GW501516 enhanced pro-inflammatory gene expressions (COX-2, IL-6, IL-8 and MCP-1) in inflamed colon. Further analysis showed that GW501516 increased the expressions of Glut1 and SLC1A5 in colon cancer cells as well as AOM/DSS-induced colorectal tumors. These findings revealed a new mechanism of PPARδ agonist GW501516-mediated colitis-associated colorectal cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLITIS
*STEROID receptor coactivators
*PEROXISOMES
*COLON cancer
*CANCER cells
Subjects
Details
- Language :
- English
- ISSN :
- 00142999
- Volume :
- 842
- Database :
- Academic Search Index
- Journal :
- European Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 133555254
- Full Text :
- https://doi.org/10.1016/j.ejphar.2018.10.050