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Prognostic Factors after Percutaneous Radiofrequency Ablation in the Treatment of Hepatocellular Carcinoma. Impact of Incomplete Ablation on Recurrence and Overall Survival Rates.
- Source :
-
Journal of Gastrointestinal & Liver Diseases . Dec2018, Vol. 27 Issue 4, p399-407. 9p. - Publication Year :
- 2018
-
Abstract
- Aims: To report on the long-term impact of tumor and non-tumor related parameters on local recurrence, distant recurrence and survival in patients with naïve or recurrent type hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA). Methods: We performed 240 RFA sessions on 133 patients with 156 HCC nodules developed on a background of liver cirrhosis and analyzed the outcomes. Results: Contrast-enhanced ultrasound performed one month after RFA showed complete ablation in 119 out of 133 (89.65%) patients. With a median follow-up of 46 months, 3-, 5- and 7-year survival rates were 61.7%, 35.7%, and 22.6%, respectively. Previous ethanol injection and histological grade were significantly related to local tumor progression. Child-Pugh class, incomplete ablation, histological grade, previous ethanol injection, alpha-fetoprotein level before the treatment, and local recurrence were all significantly related to distant recurrence. Multivariate analysis demonstrated that age, Child-Pugh class, distant recurrence and multiple incomplete ablations were significantly related to survival. Conclusion: Radiofrequency ablation could be locally curative for HCC, resulting in a survival longer than 7 years. Previous ethanol injection and incomplete ablations were strongly associated with poor outcomes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18418724
- Volume :
- 27
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Gastrointestinal & Liver Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 133547529
- Full Text :
- https://doi.org/10.15403/jgld.2014.1121.274.pro