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Synthesis and neuropharmacological evaluation of R(-)-N-alkyl-11-hydroxynoraporphines and their esters
- Source :
-
Bioorganic & Medicinal Chemistry . Jul2004, Vol. 12 Issue 13, p3553-3559. 7p. - Publication Year :
- 2004
-
Abstract
- We synthesized several N-substituted-11-hydroxynoraporphines and their esters of varying chain length, evaluated their binding affinity at dopamine (DA) receptor sites in rat caudate-putamen membranes, and quantified their effects on motor activity in normal adult male rats. The 11-hydroxyaporphines showed similar neuropharmacological properties to the corresponding 10,11-catecholaporphines. At moderate doses, their esters proved to have more prolonged behavioral actions and superior oral bioavailability. [Copyright &y& Elsevier]
- Subjects :
- *ESTERS
*DOPAMINE
*CATECHOLAMINES
*BIOAVAILABILITY
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 12
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 13350086
- Full Text :
- https://doi.org/10.1016/j.bmc.2004.04.029