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6′-Fluoro-3-deazaneplanocin: Synthesis and antiviral properties, including Ebola.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2018, Vol. 28 Issue 23/24, p3674-3675. 2p. - Publication Year :
- 2018
-
Abstract
- Graphical abstract Abstract A convenient stereospecific synthesis of 6′-fluoro-3-deazaneplanocin (6) has been accomplished from d -ribose in 15 steps. It is reported to possess significant activity towards Ebola (Zaire, Vero, μM: EC 50 < 0.36; CC 50 125; SI > 347) with moderate inhibition of the target enzyme (S-adenosylhomocysteine hydrolase), which did not correlate directly with its anti-Ebola effects. Compound 6 , with limited cytotoxicity, also displayed activity against measles, H1N1 and Pichinde. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 28
- Issue :
- 23/24
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 133498488
- Full Text :
- https://doi.org/10.1016/j.bmcl.2018.10.030