Predictors of Glycemic Control in Patients with Type 2 Diabetes: A Subgroup Analysis of the Observational Registry of Basal Insulin Treatment Study in China.

Aims: To assess predictors of glycemic control after patients with type 2 diabetes mellitus (T2DM), inadequately controlled with oral antidiabetic drugs (OADs), were initiated basal insulin (BI) in the Observational Registry of BI Treatment study in China. Materials and Methods: This multicenter, 6-month prospective registry study included patients, ages 18–80 years, who enrolled in secondary and tertiary hospitals, representative of the eight geographic regions in China. In this subgroup analysis of patients who completed the 6-month follow-up, relationship between several variables and glycemic control (glycosylated hemoglobin [HbA1c] <7%) at 6 months was examined using logistic regression. Results: Overall, 16,271 completed the 6-month visit and were included in this subgroup analysis. At 6 months, mean HbA1c was 7.4% ± 1.4%. Multivariate logistic regression analysis showed significant independent associations between a higher HbA1c control rate with frequent self-monitoring of blood glucose (SMBG) at baseline (odds ratio [OR] = 1.02; P < 0.0001), continuous use of BI (OR = 1.56; P < 0.05), and increased SMBG frequency at 6 months (OR = 1.02; P < 0.0001). Large insulin dose at 6 months [0.25–0.35 IU/(kg·day): OR = 0.64 and ≥0.35 IU/(kg·day): OR = 0.63; P < 0.05], higher HbA1c levels at baseline (OR = 0.80; P < 0.0001), longer duration of diabetes (OR = 0.97; P = 0.0002), and more OADs at baseline (2 OADs: OR = 0.81 and ≥3 OADs: OR = 0.63; P < 0.0001) were associated with a lower HbA1c control rate. Conclusions: The major predictors of good glycemic control after the initiation of BI therapy in T2DM patients were lower baseline HbA1c levels, consistent use of BI, frequent SMBG at baseline and increase in the frequency of SMBG, shorter duration of diabetes, and fewer OADs at baseline. [ABSTRACT FROM AUTHOR]