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Novel 4-hydroxycoumarin derivatives: Inhibiting growth of human lung cancer cells.
- Source :
-
Main Group Chemistry . 2018, Vol. 17 Issue 4, p301-307. 7p. - Publication Year :
- 2018
-
Abstract
- The reaction of 4-hydroxycoumarin with aromatic aldehyde and malononitrile (or ethyl cyanoacetate) gave two kinds of 4-hydroxycoumarin derivatives (1–6) and their structures were characterized via IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The in vitro anticancer activity of the synthesized products was studied and evaluated, in which four human lung cancer cells (A549, NCI-H1299, H1650 and PC9) were used in the screening tests. The results showed that compared with compounds 1–3, compounds 4–6 with ethyl ester group exerted rather potent activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10241221
- Volume :
- 17
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Main Group Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 133390301
- Full Text :
- https://doi.org/10.3233/MGC-180677