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Gemcitabine/cisplatin versus methotrexate/vinblastine/doxorubicin/cisplatin for muscle-invasive bladder cancer: A systematic review and meta-analysis.
- Source :
-
Journal of Cancer Research & Therapeutics . Oct2018, Vol. 14 Issue 6, p1260-1265. 6p. - Publication Year :
- 2018
-
Abstract
- <bold>Objective: </bold>The objective of this study was to perform a systematic review and meta-analysis to evaluate the two most commonly used chemotherapy regimens gemcitabine plus cisplatin (GC) and methotrexate, vinblastine, doxorubicin/adriamycin, and cisplatin (MVAC) regimens for muscle-invasive bladder cancer (MIBC) patients.<bold>Methods: </bold>We searched for all studies investigating GC and MVAC for MIBC patients in PubMed, Web of Knowledge, and the Cochrane Central Search Library. A systematic review and meta-analysis were performed.<bold>Results: </bold>Our searches identified 13 studies among 2174 patients. In the meta-analysis, the pathological complete response to GC regimens was superior to MVAC regimens. No significant difference in pathological partial response was found between the two groups. GC regimens were associated with a significant decrease risk in Grade 3-4 neutropenia, mucositis, and febrile neutropenia, but a significant increase risk in Grade 3-4 thrombocytopenia. There was no significant difference in overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS) when compared GC regimens to MVAC regimens.<bold>Conclusions: </bold>GC regimens significantly improved pathological complete response compared to MVAC regimens. GC regimens were associated with a significant decrease risk in Grade 3-4 neutropenia, mucositis, and febrile neutropenia, but a significant increase risk in Grade 3-4 thrombocytopenia. There was no significant difference in OS, DSS, and DFS when compared the two regimens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CISPLATIN
*BLADDER cancer
*SYSTEMATIC reviews
*META-analysis
*NEUTROPENIA
*ANTINEOPLASTIC agents
*CANCER invasiveness
*COMPARATIVE studies
*DOXORUBICIN
*RESEARCH methodology
*MEDICAL cooperation
*METHOTREXATE
*MUSCLE tumors
*PROGNOSIS
*RESEARCH
*SURVIVAL
*VINBLASTINE
*EVALUATION research
*DEOXYCYTIDINE
BLADDER tumors
Subjects
Details
- Language :
- English
- ISSN :
- 09731482
- Volume :
- 14
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Cancer Research & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 133271067
- Full Text :
- https://doi.org/10.4103/0973-1482.188434