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Magee Equation Recurrence Score Is Associated With Distal Metastatic Risk in Male Breast CarcinomasExperience From Two Institutions.

Magee Equation Recurrence Score Is Associated With Distal Metastatic Risk in Male Breast CarcinomasExperience From Two Institutions.

Authors :
Hou, Yanjun
Moosavi, Harrison S
Wei, Lai
Parwani, Anil V
Li, Xiaoxian (Bill)
Li, Zaibo
Source :
American Journal of Clinical Pathology. Dec2018, Vol. 150 Issue 6, p491-498. 8p. 2 Color Photographs, 5 Charts.
Publication Year :
2018

Abstract

Objectives To conduct a clinicopathologic study of male breast carcinoma with Magee equation recurrence score (RS). Methods Seventy-four cases of male invasive breast cancers (MBCs) were studied, including 63 hormone receptor (HR)-positive, 10 human epidermal growth factor receptor 2-positive, and one triple-negative breast cancers. Results Among 63 HR-positive MBC patients, nine patients developed distal metastasis. Statistical analysis demonstrated distal metastasis was significantly associated with positive lymph node, high Nottingham grade, and increased Magee equation RS. All HR-positive MBCs were further stratified into two categories (low RS <18; intermediate/high RS ≥18). There was a significantly increased risk for distal metastasis in MBCs with intermediate/high Magee equation RS, but no increased risk for lymph node metastasis. Conclusions Our data suggest Magee equation RS may be useful to predict distal metastatic risk in MBC patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00029173
Volume :
150
Issue :
6
Database :
Academic Search Index
Journal :
American Journal of Clinical Pathology
Publication Type :
Academic Journal
Accession number :
133211677
Full Text :
https://doi.org/10.1093/ajcp/aqy078