Packed Column Supercritical Fluid Chromatography -- Mass Spectrometry for Drug Discovery Applications.

In the last five years, the acceptance and implementation of packed-column supercritical fluid chromatography-mass spectrometry (pSFC-MS) to drug discovery applications has gained momentum. This article describes the pros and cons of pSFC-MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment structure characterization and purification. Finally, an outlook for the future of this technique is presented. [ABSTRACT FROM AUTHOR]